ABSTRACT
Objective: Periodontal disease results the production ofdifferent enzymes that are released by epithelial orinflammatory cells. There are important enzymes associatedwith cellular alteration and cell death like: Lactatedehydrogenase (LDH), Creatine Kinase (CK), Alkaline andAcidic phosphatase (ALP, ACP). Enzymatic activity changesresults in changes health and metabolic changes in Gingivaland Periodontal condition.Design of study: We have examined the activity of CK, LDH,ALP and ACP in saliva from patients with periodontal diseasebefore and after periodontal treatment (experimental group –40samples) and in saliva from healthy patients (control group –30 samples). Periodontal disease was determined based onclinical parameters (gingival index (GI), bleeding on probing(BOP), probing depth (PD). Patients with periodontal diseasewere under periodontal treatment.Results: Results showed statistically significant increases ofactivity of CK, LDH, ALP and ACP in saliva from patients withperiodontal disease in relation to control group. There ispositive correlation between the examined salivary enzymesand value of the gingival index. After periodontal therapy theactivity of all salivary enzymes was significantly decreased.Conclusions: Based on these results, it can be stated thatactivity of these enzymes in saliva, as biochemical markers forperiodontal tissue damage, may be useful in diagnosis,prognosis and evaluation of therapy effects in periodontaldisease.